Hyperoxemia and Ventilator-associated Pneumonia

University Hospital, Lille534 enrolled

Overview

The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence. * SpO2 will be continuously recorded in order to determine the percentage of time spent with hyperoxemia. * Patients with VAP will be prospectively identified. * Patient characteristics and risk factors for VAP will be prospectively collected. * Oxidant stress will be prospectively investigated in study patients: glutathion peroxidase (GPX), plasmatic superoxyde dismutase (SOD), total plasmatic antioxidant status (SAT) and urinary 8-isoprostanes will be performed at ICU admission, once a week, and at VAP occurrence. Patients with VAP will be compared with those with no VAP

Study Type

OBSERVATIONAL

Enrollment

534

Conditions

Mechanical Ventilation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients admitted to the ICU * Expected duration of mechanical ventilation \> 48h * Signed informed consent * Social insurance Exclusion Criteria: * Pregnancy or breast feeding * No informed consent * Hyperbaric oxygen treatment * Prisoners and patients under guardianship

Locations (1)

CHU de Lille

Lille, France

Outcomes

Primary Outcomes

VAP occurrence

hyperoxemia at ICU admission (PaO2 \>120 mmHg)

Time frame: 28 days after ICU admission

Secondary Outcomes

percentage of time spent with hyperoxemia during ICU stay

hyperoxemia is defined as peripheral O2 saturation (SaO2)\>98%, SaO2 will be measured every 30 seconds, and the percentage of time spent with hyperoxemia will be calculated per day.

Time frame: 28 days after ICU admission

relationship between hyperoxemia at ICU admission and the presence of acute lung injury (ALI)

the presence of hyperoxemia at ICU admission will be determined using blood gazes (arterial PaO2\>120 mmHg). The percentage of patients with hyperoxemia will be compared between patients with Ali, and those with no ALI

Time frame: 28 days after ICU admission

percentage of time spent with hyperoxemia during ICU stay, and the presence of acute lung injury

the percentage of time spent with hyperoxemia during ICU stay will be calculated as mentioned above (outcome 2). This percentage will be compared between patient with ALI and those with no ALI

Time frame: 28 days after ICU admission