Durvalumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer

Inclusion Criteria: 1. Histologically or cytologically confirmed adenocarcinoma of the colon or the rectum. 2. Mismatch repair deficient or microsatellite instable (defined below), or POLE mutated tumors A. Mismatch repair deficient: loss of expression by immunohistochemical stains ≥ 1 out of 4 markers (MLH1, MSH2, MSH6, PMS2) B. Microsatellite instable: loss of stability ≥2 out of 5 gene panels (BAT-25, BAT-26, D2S123, D5S346, D17S250) 3. Refractory to at least one agent of prior treatments(fluoropyrimidines, irinotecan or oxaliplatin) Progressed after at least first-line systemic chemotherapy for metastatic setting (progressed within 6 months after completion of adjuvant chemotherapy is also considered as first-line failure) 4. ≥ 1 measurable lesion(s) by RECIST 1.1. 5. Unresectable advanced or metastatic disease. 6. Age over 20 years old. 7. ECOG performance status of 0-1 or lower. 8. Adequate organ functions. A. Bone marrow function: Hemoglobin 9.0≥ g/dL, ANC≥ 1,500/mm3, platelet≥ 100,000/mm3 B. Hepatic functions: bilirubin ≤ 1.5 X ULN, AST/ALT ≤ 2.5 X ULN (≤ 5 X ULN in cases of liver metastasis) C. Renal functions: serum Cr ≤ 1.5 X ULN or calculated CCr (Cockcroft) \> 40 ml/min 9. Be willing and able to comply with the protocol for the duration of the study. 10. Give written informed consent prior to study-specific screening procedures, with the understanding that the patient has the right to withdraw the study at any time, without prejudice. 11. Female subjects must either be of non-reproductive potential (≥ 60 years old and no menses for ≥ 1 year without an alternative medical cause, or history of hysterectomy, or history of bilateral tubal ligation, or history of bilateral oophorectomy) or must have a negative serum pregnancy test upon study entry. 12. Women of childbearing potential and men must agree to use adequate contraception since signing of the IC form until at least 90days after the last study drug administration. Exclusion Criteria: 1. Any prior treatment with PD-1 or PD-L1 inhibitor, including durvalumab. 2. Involvement in the planning and/or conduct of the study. 3. Receipt of the last dose of chemotherapy ≤ 28 days prior to the first dose of study drugs. 4. Mean QT interval corrected for heart rate (QTc) ≥ 470 msec calculated from 3 electrocardiograms (ECGs) using Frediricia's Correction. 5. Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the exception of alopecia, vitiligo, and the laboratory values defined in the inclusion criteria 6. Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis after consultation with the Study Physician. 7. Patients with irreversible toxicity not reasonably expected to be exacerbated by treatment with durvalumab may be included only after consultation with the Study Physician. 8. Any concurrent chemotherapy, IP, biologic, or hormonal therapy for cancer treatment. Concurrent use of hormonal therapy for non-cancer-related conditions (eg, hormone replacement therapy) is acceptable. 9. Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiologic doses, which are not to exceed 10 mg/day of prednisolone, or an equivalent corticosteroid. 10. Concurrent or previous history of another primary cancer within 3 years prior to randomisation except for curatively treated cervical cancer in situ, non-melanomatous skin cancer, superficial bladder cancer (pTis and pT1) and curatively treated thyroid cancer of any stage. Concurrent, histologically confirmed, unresected thyroid cancer without distant metastasis could be allowed with the agreement of the chief principal investigator. 11. Uncontrolled CNS metastases; permitted if asymptomatic or neurologically stable. 12. Prior radiation therapy would be permitted, but non-radiated evaluable lesions should be present at study entry. 13. Radiation therapy during study treatment is not permitted, but if the local investigator decides that radiation therapy should be given during study treatments, he should be convinced that there is no evidence of disease progression with agreement of the chief principal investigator. 14. Congestive heart failure ≥ New York Heart Association (NYHA) class 2. 15. Unstable angina, new-onset angina within 3 months, or history of myocardial infarction within 6 months before the study entry. 16. Active or prior documented autoimmune disease within the past 2 years; subjects with vitiligo, Grave's disease, or psoriasis not requiring systemic treatment (within the past 2 years) are not excluded. 17. Active or prior documented inflammatory bowel disease. 18. History of prior immunodeficiency. 19. History of allogeneic organ transplantation. 20. History of hypersensitivity to durvalumab or any excipient. 21. History of previous clinical diagnosis of active tuberculosis. 22. Receipt of live attenuated vaccination within 30 days prior to study entry. 23. Known history of testing positive for HIV 24. Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection at screening (positive HBV surface antigen or HCV RNA if anti-HCV antibody screening test positive) Except, resolved HBV infection (as evidenced by detectable HBV surface antibody, detectable HBV core antibody, undetectable HBV DNA, and undetectable HBV surface antigen) or Chronic HBV infection (as evidenced by detectable HBV surface antigen or HBV DNA). Subjects with chronic HBV infection must have HBV DNA \< 100 IU/mL and must be on antiviral therapy. 25. Major surgery or significant traumatic injury within 28 days prior to study treatment. 26. Non-healing wound, ulcer, or bone fracture. 27. Current evidence of significant gastrointestinal bleeding or (impending) obstruction. 28. Concomitant participation in another clinical trial. 29. Pregnant of breast-feeding subjects. Women of child-bearing potential must have pregnancy test within 7 days and a negative result must be documented before start of study treatment. 30. Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study results.