This study investigates functional outcome and safety after one-stage versus two-stage revision of the infected knee arthroplasty. Half of participants are treated with a one-stage surgical procedure, while the other half is treated with a two-stage procedure. The investigators hypothesize that the functional outcome and quality of life of the participants is superior after one-stage surgery compared to two-stage surgery.
A two-stage approach is the standard surgical procedure in the treatment of the chronically infected knee arthroplasty, but promising results have been reported after a one-stage approach from single-centre studies. The potential benefits for the patients treated with a one-stage approach are many as they only have to go through surgery and rehabilitation once with shorter total length of hospital stay. However, no randomized controlled trials comparing outcome after the procedures have been performed so far.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
97
Aalborg University Hospital
Aalborg, Denmark
Bispebjerg Hospital
Copenhagen, Denmark
Gentofte Hospital
Copenhagen, Denmark
Hvidovre Hospital
Copenhagen, Denmark
Oxford Knee Score (AUC)
Area Under Curve for Oxford Knee Score
Time frame: preoperatively 6 weeks, 3, 6, 9, 12 months postoperatively.
Oxford Knee Score (AUC)
Area Under Curve for Oxford Knee Score
Time frame: preoperatively, 6 weeks, 3, 6, 9, 12, 18 and 24 months postoperatively.
EQ-5D-5L
Quality of life questionnaire
Time frame: preoperatively, 6 weeks, 3, 6, 9, 12, 18 and 24 months postoperatively.
Re-revision rate
re-revisions due to infection and other causes
Time frame: 2 year postoperatively
mortality
postoperative mortality
Time frame: 90 days postoperatively and 1 and 2 year postoperatively
readmission rate
postoperative readmission rate
Time frame: 90 days postoperatively
Range of Motion
Range of motion of the infected/operated knee
Time frame: 2 years postoperatively
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Rigshospitalet
Copenhagen, Denmark
Horsens Hospital
Horsens, Denmark
Næstved Hospital
Næstved, Denmark
Odense Universitets Hospital
Odense, Denmark
Vejle Hospital
Vejle, Denmark