Atrial and Ventricular Wall Stress During Breathing

Umeå University40 enrolled

Overview

Healthy reclining adult volunteers, with Valsalva manoeuver, Muller manoeuver, light continuous positive airway pressure by mask, passive leg raising, and maximal hand-grip. Ultrasound heart images captured before and during.

With focus on atrial wall strain and strain-rate, In healthy volunteer adult subjects, heart ultrasound is recorded during resting, Valsalva manoeuver, Muller manoeuver, passive leg raising, and handgrip. Echocardiographic recordings are made before and during each intervention. Participants are otherwise resting in a reclined position.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Simple breathing manuevers during brief echocardiographic imagingOTHER

Valsalva, Muller, light mask CPAP, leg raising, hand grip.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy adults Exclusion Criteria: * known heart or lung disease

Locations (1)

Umeå University, and the University Hospital of Umeå

Umeå, Sweden

Outcomes

Primary Outcomes

Change in atrial wall stress during breathing manoeuver, compared to control measurement immediately before the breathing manoeuver

Echocardiographic measure, comparing control measurement to measurement during breathing manoeuver

Time frame: 30 seconds, i.e. control measurement and then measurement during breathing manoeuver observed from same breathing/measurement sequence

Data from ClinicalTrials.gov

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