Repetitive Levosimendan Infusion for Patients With Advanced Chronic Heart Failure

Inclusion Criteria: 1. Written, signed and dated informed consent. 2. Male and female patients over 18 years of age. 3. Women of childbearing potential must have a monthly negative pregnancy test and must refrain from breastfeeding. Women who are postmenopausal (1 year since last menstrual cycle), surgically sterilised or who have undergone a hysterectomy are considered not to be of childbearing potential. 4. CHF diagnosed at least 6 months before screening and treated with individually optimised long-term oral treatment for the last month, unless not tolerated (e.g., ACE-inhibitor or AT II blocker, beta-blocker, mineralocorticoid receptor antagonist, angiotensin II receptor blocker neprilysin inhibitor \[ARNI\] and with devices \[e.g., CRT/ICD\], as needed). 5. Left ventricular ejection fraction less than or equal to 30% as assessed by echocardiography, radionuclide ventriculography or contrast angiography within the index hospitalisation. 6. Currently hospitalised for decompensated HF requiring i.v. diuretics, or i.v. vasodilators, or i.v. inotropic therapy, or their combination. 7. Previous hospitalisation or visit to outpatient clinic requiring i.v. diuretics, i.v. vasodilators, or i.v. inotropic therapy, or their combination for acute decompensated HF within 12 months before the current hospitalisation. 8. NT-proBNP level after recompensation of more or equal 2500 ng/L (BNP more or equal 900 ng/L) and/or NYHA class III or IV at study entry Exclusion Criteria: 1. Severe obstruction of ventricular outflow tracts such as haemodynamically significant uncorrected primary valve disease or hypertrophic cardiomyopathy or impaired ventricular filling such as restrictive cardiomyopathy. 2. Predominantly right heart failure a/o severe tricuspid regurgitation 3. Cardiac surgery or coronary angioplasty within 30 days before study drug initiation. 4. Acute coronary syndrome within 30 days before study drug initiation. 5. Patients who are scheduled for cardiac surgery or angioplasty in the next 3 months 6. History of torsades de pointes 7. Stroke or transient ischaemic attack (TIA) within 3 months before study drug initiation 8. Systolic blood pressure less than 90 mmHg at baseline 9. Heart rate 120 bpm or greater at baseline 10. Serum potassium less than 3.5 mmol/l before study drug initiation. 11. Severe renal insufficiency (estimated glomerular filtration rate (eGFR) \<30 ml/min/1.73m2) 12. Anaemia (haemoglobin \< 10 g/dl) 13. Significant hepatic impairment at the discretion of the investigator. 14. Hypersensitivity to levosimendan 15. Other serious diseases limiting life expectancy considerably (e.g. end-stage cancer, end-stage lung disease) 16. Participation in a clinical trial with any experimental treatment within 30 days prior to screening or previous participation in the present study 17. Administration of levosimendan within 14 days prior the study drug initiation, the first study drug application has to be postponed for at least 14 days after the end of this premedication 18. Suspected non-compliance 19. Pregnant woman and nursing mother 20. Failure to use highly-effective (Pearl Index lower than 1%) contraceptive methods. 21. Person with any kind of dependency on the investigator 22. Person held in an institution by legal or official order