Research studies in stuttering have shown that activity patterns in certain brain areas differ in people who stutter compared to people who do not stutter when speaking. The purpose of this study is to investigate how mild, non-invasive brain stimulation applied consecutively for five days affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people who stutter.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
29
20 minutes of 2mA anodal stimulation.
Speaking along with a metronome and/or speaking along with another person (choral speech) for 20 minutes
For sham stimulation, current is ramped up and back down over 30 seconds.
University of Michigan
Ann Arbor, Michigan, United States
Changes in Brain Activation as Assessed by fMRI Images
Investigators will use the fMRI images taken from before and after tDCS to determine if the treatment intervention contributed to any changes within brain regions associated with speech production. This will be measured by Blood-Oxygen-Level-Dependent (BOLD) signal change (arbitrary units). Images from scans are preprocessed. Changes in BOLD signal are modeled for contrasts within a group for \[post-pre\] and \[follow up-pre\] (e.g., active group reading condition post visit MINUS active group reading pre visit). Results are reported for reading condition.
Time frame: Baseline, 1 week (post), 4 weeks (follow up)
Change in Percentage of Stuttered Syllables Produced During Speech Sample
Investigators will calculate the percentage of stuttered syllables (out of total syllables) in a speech sample. Decreased stuttered syllables represents better outcomes (greater reduction in stuttering).
Time frame: Baseline, 1 week (post), 4 weeks (follow up)
Changes From Baseline on the Overall Assessment of Speakers Experience of Stuttering (OASES)
The OASES is a standardized assessment of the functional impact of stuttering on a person's life. There are 4 sub-tests: general information about speech, your reactions to stuttering, communication in daily situations, quality of life. Each one has a score from 1 to 5 with regard to impact (1 least, 5 most negative impact). These are combined to give a total impact score between 1 and 5, with 5 representing the highest negative impact on person's life. The change on the total impact score will be used. Changes are shown in the table below by comparison between the measurements at the three points in time.
Time frame: Baseline, 1 week (post), 4 weeks (follow up)
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