Reduction Ratio and Clearance During Hemodialysis With MCO-filter Compared to HDF With Standard High-flux Filter

Region Skane18 enrolled

Overview

The Medium Cut-Off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters. The major aim of this study is to compare the reduction ratio of middle molecules, during a single hemodialysis session with MCO-filter, compared to hemodiafiltration (HDF) with standard high-flux filter. Secondary aims are to compare the reduction ratio of small and large molecules between the treatments.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Kidney Failure Uremia Dialysis

Interventions

MCO-HDDEVICE

Measurements will be done during a single hemodialysis session with Medium Cut-Off filter

High-flux HDFDEVICE

Measurements will be done during a single hemodiafiltration session with standard high-flux filter

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ongoing HDF treatment * CRP \<30 * No Acute Myocardial Infarction within 3 months. Exclusion Criteria: * Not able to understand the study information.

Locations (1)

Skane University Hospital

Malmo, Sweden

Outcomes

Primary Outcomes

Reduction ratio (RR) of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)

Reduction ratio during a 4h dialysis session. (Predialysis concentration - Postdialysis concentration)/Predialysis concentration\*100%

Time frame: 4 hours

Instantaneous arteriovenous clearance of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)

Instantaneous arteriovenous clearance (ml/min) at 30 minutes of dialysis.

Time frame: 30 minutes

Instantaneous arteriovenous clearance of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)

Instantaneous arteriovenous clearance (ml/min) at 60 minutes of dialysis.

Time frame: 60 minutes

Instantaneous arteriovenous clearance of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)

Instantaneous arteriovenous clearance (ml/min) at 120 minutes of dialysis.

Time frame: 120 minutes

Instantaneous arteriovenous clearance of middle molecules (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin)

Instantaneous arteriovenous clearance (ml/min) at 240 minutes of dialysis.

Time frame: 240 minutes

Secondary Outcomes

RR of large molecules (Albumin, Transferrin, IgG)

Reduction ratio during a 4h dialysis session. (Predialysis concentration - Postdialysis concentration)/Predialysis concentration\*100%

Time frame: 4 hours

Data from ClinicalTrials.gov

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