In this study, the investigators aim to assess if vitamin B12 treatment demonstrates a beneficial effect on voice performance. If so, they wish to examine the relationship between the vitamin B12 treatment and the study participant's general well-being.
Through the investigators' experience, they have observed that amongst singers and voice professionals, there is a common belief that there are voice benefits from cobalamin treatment. Consequently, some singers and voice professionals tend to ask for cobalamin injections in order to enhance their vocal performance. However, there are no previous reports that illustrate the effects of vitamin B12 deficiency or treatment on voice performance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
20
1,000 mg, Once
0.9% Sodium Chloride, Once
Keck Medicine of USC - Downtown Los Angeles
Los Angeles, California, United States
Evaluation of the Ability to Sing Easily (EASE) - Change
1 = Not at All, 2 = Mildly, 3 = Moderately, 4 = Extremely
Time frame: Baseline, 1 Hr Post-Injection, 3 Hrs Post-Injection, 24 Hrs Post-Injection, 72 Hrs Post-Injection, 1 Wk Post-Injection
Singing Voice Handicap Index-10 (SVHI-10) - Change
0 = Never, 1 = Almost Never, 2 = Sometimes, 3 = Almost Always, 4 = Always
Time frame: Baseline, 1 Hr Post-Injection, 3 Hrs Post-Injection, 24 Hrs Post-Injection, 72 Hrs Post-Injection, 1 Wk Post-Injection
0-10 Visual Analog Scale (VAS) - Change
The scale asks, "How confident are you that your voice will do what you need it to do right now?"; 0 = Not Confident At All, 10 = Extremely Confident
Time frame: Baseline, 1 Hr Post-Injection, 3 Hrs Post-Injection, 24 Hrs Post-Injection, 72 Hrs Post-Injection, 1 Wk Post-Injection
Vocal Fold Swelling (Bastian et al., 2009) - Change
Happy Birthday, Staccato, Trill; 1 = Poor, 5 = Average, 10 = Excellent
Time frame: Baseline, 1 Hr Post-Injection, 3 Hrs Post-Injection, 24 Hrs Post-Injection, 72 Hrs Post-Injection, 1 Wk Post-Injection
Voice Fatigue Index (VFI) - Change
0 = Never, 1 = Almost Never, 2 = Sometimes, 3 = Almost Always, 4 = Always
Time frame: Baseline, 1 Hr Post-Injection, 3 Hrs Post-Injection, 24 Hrs Post-Injection, 72 Hrs Post-Injection, 1 Wk Post-Injection
Short Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS) - Change
1 = Not at All, 5 = Extremely
Time frame: Baseline, 1 Hr Post-Injection, 3 Hrs Post-Injection, 24 Hrs Post-Injection, 72 Hrs Post-Injection, 1 Wk Post-Injection
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Patients Health Questionnaire-9 for Depression - Change
0 = Not at All, 3 = Extremely
Time frame: Baseline, 1 Hr Post-Injection, 3 Hrs Post-Injection, 24 Hrs Post-Injection, 72 Hrs Post-Injection, 1 Wk Post-Injection