This is a Randomized Controlled Trial . The purpose of this study is to assess the hypothesis that whether a high protein diet combined with a physical activity protocol in surgical cancer patients admitted to the ICU in the post operative period is associated with better physical function at the hospital discharge as well as a better quality of life.
Surgical cancer patients will be categorized by their nutritional risk using a specific screening toll. During the hospital stay some measurements will be done. Such as resting energy expenditure (REE) before and after surgery; physical function evaluation; strength and quality of life. The proposed intervention is a post operative diet with a different amount of protein (diet with a standard amount of protein and a diet with high amount of protein) associated to an institutional protocol of physical activity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
126
Enteral feeding that will give the patient the amount of protein between 2.0 - 2.5 Kg/body weight/Day
Enteral feeding that will give the patient the amount of protein between 1.0 - 1.2 Kg/body weight/Day
Faculty of Medicine University of Sao Paulo
São Paulo, São Paulo, Brazil
Physical Function
6 minutes walk test
Time frame: 8 days after randomization
Physical Function
6-minute walk test after 30 days the date of randomization;
Time frame: 30 days after randomization
Quality of life
Measurement of quality of life using the Euro-Qol 5D-5L index. EQ-5D-5L index includes five questions concerning mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. A summary utility index value can be computed from subject's response to these five questions. Values range from -0.594 (worst possible health score) to 0 (death) to 1.000 (best health).
Time frame: 6 months after randomization
Body Composition related to prognosis
Phase Angle (BIA)
Time frame: 8 days after randomization
Postoperative complications
Clavien Dindo
Time frame: 30 days after randomization
Resting Energy Expenditure
Indirect Calorimetry
Time frame: one day before surgery and one day after surgery
Length of hospital stay.
Starts in the first day of hospitalization and ends on the day of hospital discharge
Time frame: 30 days after randomization
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