Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.

Universitaire Ziekenhuizen KU Leuven30 enrolled

Overview

WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset

First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid. Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed. Finally in a small subset of ECMO patients PK exposure will be explored.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pharmacokinetics Critical Illness

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pneumonia * Admitted to an ICU ward * Treated with ceftriaxone Exclusion Criteria: * Pregnancy * DNR code 2-3 * Renal replacement therapy

Locations (1)

UZLeuven

Leuven, Belgium

Outcomes

Primary Outcomes

Risk factors for target non attainment

risk factors will be assessed by comparing patients who attain target vs. those who don't

Time frame: on day of sampling

Data from ClinicalTrials.gov

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