Low Intensity Exercise in Different Normobaric/Hypobaric Normoxic/Hypoxic Conditions.

Fliegerärztliches Institut20 enrolled

Overview

The main goal of this project is to investigate how low intensity cycling exercise (1.5W/kg, for 6 minutes) influences cerebral functions, such as: Cerebral blood flow, oxygenation, and other physiological variables in different normobaric and hypobaric hypoxic conditions.

Subjects will bike at 1W/kg for 6 minutes at different simulated altitude level in the hypobaric chamber at the FAI in Dübendorf. Concentration performance also will be measured to better understand how hypobaric and hypoxia conditions may affect physiological responses, cerebral and cognitive functions.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Baro-reflex Sensitivity Heart Rate Variability EEG, Microstates Cerebral Blood Flow Regulation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Study Indication * Male and Female subjects from 18 years to 40 years of age * Healthy volunteer * Signed Informed Consent after being informed Exclusion Criteria: * Contraindications to the study intervention. * Define drugs, treatments or interventions not allowed during the study or for specific periods of time prior to the intervention, * Women who are pregnant or breast feeding, * Intention to become pregnant during the course of the study, * Known or suspected non-compliance, drug or alcohol abuse, * Previous problem with hypoxia or altitude exposure, * Known pathologies/diseases * Relevant medical disorders * Anemia or poor health * History of flight sickness

Outcomes

Primary Outcomes

Baro-reflex sensitivity

To test the strength of relationship between RR interval and systolic blood pressure in human. Measurement before and after low intensity exercise in each condition.

Time frame: 6 minutes per record.

Secondary Outcomes

Concentration performance

Subjects will conduct a concentration test in each condition.

Time frame: 4 minutes per test

EEG microstates

Microstates analysis to investigate how electrical cerebral activity is affected at rest in hypoxia and influenced by low intensity cycling exercise.

Time frame: 6 minutes per record

Heart rate variability (HRV)

To investigate about stress (sympathetic and parasympathetic activation) in each condition tested.

Time frame: 6 minutes per record

Cerebral blood flow

Regulation of cerebral blood flow in hypoxia at rest and during low-intensity exercise. Measurement before, during and after low intensity exercise in each condition. 6 minutes recording per measurement.