Effect of Galactose Ingestion on Postprandial Lipemia

University of Bath10 enrolled

Overview

This study aims to assess the postprandial triglyceride response to the ingestion of a high-fat meal with co-ingestion of either galactose, or glucose.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Cardiovascular Risk Factor Lipemia

Interventions

GalactoseDIETARY_SUPPLEMENT

Co-ingestion of d-galactose with a high-fat meal

GlucoseDIETARY_SUPPLEMENT

Co-ingestion of d-glucose with a high-fat meal

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * 18 to 35 years old * Body mass index \<30 kg/m2 Exclusion Criteria: * Female * Body mass index \>29.9 kg/m2 * Any history of metabolic disease * Allergies or intolerances to milk and/or cream

Locations (1)

Department for Health, University of Bath

Bath, United Kingdom

Outcomes

Primary Outcomes

Postprandial increase plasma triglyceride concentrations

Incremental area under the curve (iAUC) of plasma triglyceride concentrations

Time frame: 5 hours

Secondary Outcomes

Postprandial plasma insulin concentrations

Incremental area under the curve (iAUC) of plasma insulin concentrations

Time frame: 5 hours

Postprandial plasma glucose concentrations

Incremental area under the curve (iAUC) of plasma glucose concentrations

Time frame: 5 hours

Postprandial plasma non-esterified fatty acid concentrations

Postprandial area under the curve of non-esterified fatty acid concentrations

Time frame: 5 hours

Postprandial plasma lactate concentrations

Incremental area under the curve (iAUC) of plasma lactate concentrations

Time frame: 5 hours

Postprandial subjective hunger ratings

Postprandial area under the curve of hunger ratings measured by visual analogue scales (0-100 mm)

Time frame: 5 hours

Postprandial subjective fullness ratings

Postprandial area under the curve of fullness ratings measured by visual analogue scales (0-100 mm)

Time frame: 5 hours

Postprandial subjective satisfaction ratings

Postprandial area under the curve of satisfaction ratings measured by visual analogue scales (0-100 mm)

Data from ClinicalTrials.gov

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