Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers

Inclusion Criteria: * good command of English language * right handedness * normal or corrected-to-normal vision Exclusion Criteria: * personal history or active presence of psychiatric conditions * usage of psychotropic medication within the past 3 months * pregnancy or breast-feeding status * systolic blood pressure \< 90 mmHg or \> 140 mmHg at screening visit * diastolic blood pressure \< 50 mmHg or \> 90 mmHg at screening visit * resting heart rate \< 45 beats/minute or \> 100 beats/minute at screening visit * active presence of medical condition at physical examination * history of major traumatic brain injury * any other contraindication to MRI of the brain * use of psychoactive substances incl. alcohol in 24 hours prior to test session