The Therapeutic Effect of BET in COM With ETD

Inclusion Criteria: 1. Patients who need tympanoplasty, with clear diagnosis of chronic otitis media, middle ear cholesteatoma; 2. Patients with eustachian tube dysfunction using TMM; 3. Subjects or their legal representatives can understand the purpose of the study, show sufficient compliance with the research protocol, and sign the informed consent form. Exclusion Criteria: 1. Secondary chronic otitis media (after head and neck cancer radiotherapy); 2. Ipsilateral ear recurrence after surgical treatment, requiring secondary surgery; 3. Two tympanoplasty surgery; 4. Typical allergic rhinitis, nasal endoscopy or imaging studies suggest chronic rhinosinusitis, nasal polyps and other short-term eustachian tube function of a greater impact on the disease; 5. poor general health, with severe liver and kidney dysfunction, coagulation disorders, cardiovascular disease, neurological diseases can not tolerate surgery.