The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD) drink alcoholic beverages. These reactions are most often seen with red wine.
This is a prospective trial of approximately 60 subjects with AERD to explore the mechanisms behind the physiologic reactions that occur when drinking alcoholic beverages. At various time points patients will be asked to ingest a variety of substances found in red wine after which blood and urine markers of the reaction will be measured.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
60
Serum and urine markers will be obtained after drinking 5 oz of water
Serum and urine markers will be obtained after drinking 5 oz of water
Serum and urine markers will be obtained after consuming 100 mg of provinols powder
University of Virginia
Charlottesville, Virginia, United States
RECRUITING24 Hour Urinary Leukotriene-E4 (LTE4)
Urine LTE4 ng/mg Cr
Time frame: 24 hour
24 Hour Urinary Prostaglandin-D2 (PGD2) metabolite
Urine PGD2 metabolite ng/mg Cr
Time frame: 24 hour collection
Whole blood Activated Basophil Level
Proportion of activated basophils in whole blood after ingestion
Time frame: 2 hours after ingestion
Whole Blood Activated Eosinophil Level
Proportion of activated eosinophils in whole blood after ingestion
Time frame: 2 hours after ingestion
Whole Blood tryptase
Level of tryptase concentration in whole blood
Time frame: 2 hours after ingestion
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