Use of Antiseptic Solution for Vaginal Wash Before Cesarean Section

Saint Thomas Hospital, Panama203 enrolled

Overview

To evaluate the rate of infections after cesarean sections in patients with premature rupture of membranes after vaginal wash either with an antiseptic solution (clorhexidine solution) vs. saline solution (placebo).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

203

Conditions

Operation Wound; Infection Endometritis

Interventions

ClorhexidineDRUG

Vaginal wash with clorhexidine solution previous to cesarean section in patients with premature rupture of membranes.

Saline solutionDRUG

Vaginal wash with saline solution previous to cesarean section in patients with premature rupture of membranes.

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Women with gestation between 34 and 41 6/7 weeks. * Premature rupture of membranes (\> 6 hours). * Use of prophylactic antibiotic 1 hour previous to cesarean section. Exclusion Criteria: * Any source of infection diagnosed previous to surgery. * Fever of unknown origin previous to surgery.

Locations (1)

Saint Thomas Maternity Hospital

Panama City, Panama

Outcomes

Primary Outcomes

Number of cases of endometritis after cesarean section

Endometritis

Time frame: 15 days

Secondary Outcomes

Number of cases of cesarean site infection

Operative site infection

Time frame: 15 days

Number of cases of fever (38°C or above) in the puerperium

Puerperal fever

Time frame: 15 days

Data from ClinicalTrials.gov

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