Benefits of Amantadine in Patients With Coma State

Dokuz Eylul University56 enrolled

Overview

The study was a single center observational-prospective study and approved by local ethics committee. Patients in coma state due to traumatic brain injury, cardiac arrest or ischemic stroke who are older than 18 years of age were included in the study. Patients who received amantadine 200mg/day for fourteen days according to ICU protocols decided by primary physician formed the amantadine group, and the rest of the subjects were included in the control group. All patients were evaluated for Glasgow Coma Score, JFK Coma Recovery Scale and Disability Rating Scale once a week for three months.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coma; Prolonged Amantadine

Interventions

amantadine sulphateDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ≥18 years, ≤ 65 years * GCS score ≤ 8 * Coma state due to ischemic stroke, brain hemorhage, anoxic brain damage Exclusion Criteria: * \<18 years, \> 65 years * Patients admitted to the critical care without diagnosis of coma state * Patients admitted to critical care with coma state that are not duo to ischemic stroke, brain hemorhage, anoxic brain damage * Metastatic malignant neoplazm * Congenital or acquired brain function problem (cerebral palsy, autism etc) * Patients with amantadine allergy * Progressive degenerative diseases (Alzheimer, Parkinson diseases etc)

Locations (1)

Dokuz Eylul University

Izmir, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

Change in Glascow Coma Score

Glascow Coma Score

Time frame: 1. At the time of enrollment 2. 12 weeks after the enrollment

Central Contacts

Kutlay Aydin, MD

CONTACT

+905322649294 kutlayaydin@hotmail.com

Data from ClinicalTrials.gov

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