Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer

Inclusion Criteria: 1. Histologically confirmed locally advanced rectal cancer; 2. 18-70 years ； 3. Clinicalstage:T3,4a,N0,M0;T1-4a,N+,M0; 4. Tumor from anus \>5cm and ≤15cm; 5. ECOG=0-1; 6. Available organ function:ALT≤1.5xULN;AST≤1.5xULN;TBIL≤1.0xULN; NEUT≥2×109/L;PLT≥100×109/L;Hb≥90g/L;Creatinine≤1.0xULN; 7. Informed consent; 8. UGT1A1:UGT1A1\*1/UGT1A1\*1,UGT1A1\*1/UGT1A1\*28,UGT1A1\*1/UGT1A1\*6; Exclusion Criteria: 1. Clinical stage T4b or unresectable disease; 2. History of pelvic radiotherapy; 3. History of chemotherapy within 5 years; 4. History of chronic diarrhea; 5. Tumor causes intestinal obstruction, intestinal perforation, and severe bleeding; 6. Hepatitis B surface antigen positive; Hepatitis C virus infection; Cirrhosis of the liver for any cause; 7. UGT1A1:UGT1A1\*28/UGT1A1\*28,UGT1A1\*6/UGT1A1\*6; 8. Other cancers in the past 5 years, except for cervical carcinoma in situ or non-melanoma skin cancer; 9. Myocardial infarction (in the last 6 months), severe instability angina, congestive heart failure; interstitial pneumonia,pulmonary fibrosis, uncontrolled diabetes, renal insufficiency; 10. Mental illness;Pregnant or lactating women;