Impact of Short-term Fructose-enriched Diet on Serum Metabolome by Normal- and Over-weighed Women.

University of Hohenheim12 enrolled

Overview

The purpose of this study is to investigate how a high-fructose diet, either by high fructose intake from complex, natural foods or by fortifying the diet with corn syrup, affects the metabolism. Furthermore, it will be investigate if there are differences between obese and normal weight participants.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Non-Alcoholic Fatty Liver Disease Obesity

Interventions

DietOTHER

7 days fruit-rich diet, 7 days HFCS-rich diet

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adults, aged between 20 and 30 years * normal weighted (BMI ≤ 25 kg/m2) and obese (BMI 35-50 kg/m2) * written informed consent At initial medical examination an anamnesis, physical examination, blood sample collection (10 ml) was performed to check for eligibility. Furthermore, a hydrogen breath test was performed to detect potential fructose intolerance Exclusion Criteria: * smoking, * fructose intolerance/ -malabsorption, * pregnancy * chronic gastrointestinal diseases (e.g. chronic inflammatory bowel disease, irritable bowel syndrome, celiac disease etc.), * operation on the gastrointestinal tract (exclusively appendectomy) * anemia, * hepatic or renal disease * diabetes mellitus * consuming illnesses (e.g. cancer, acquired immunodeficiency syndrome (AIDS)) - drug intake affecting lipid or glucose metabolism (cholesterol- or glucose reducing or antihypertensive drugs, steroids, L-Thyroxin, antidepressants, weight reducing drugs).

Outcomes

Primary Outcomes

metabolite concentration

The primary endpoint is the change of metabolite concentration after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.