The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.
The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.
Study Type
OBSERVATIONAL
Enrollment
1,001
Open heart surgery
Turku University Hospital
Turku, Finland
Atrial fibrillation
Occurrence of atrial fibrillation
Time frame: postoperatively until 5 years follow-up
Stroke
Occurrence of stroke
Time frame: postoperatively until 5 years follow-up
Transient ischemic attack
Occurrence of Transient ischemic attack
Time frame: postoperatively until 5 years follow-up
Myocardial infarction
Occurrence of Myocardial infarction
Time frame: postoperatively until 5 years follow-up
Target vessel revascularization
Occurrence of Target vessel revascularization
Time frame: postoperatively until 5 years follow-up
All-cause Mortality
All-cause Mortality
Time frame: postoperatively until 5 years follow-up
Post-pericardiotomy syndrome
Occurrence of Post-pericardiotomy syndrome
Time frame: postoperatively until 1 years follow-up
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