Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus

Çanakkale Onsekiz Mart University40 enrolled

Overview

This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with uncontrolled type 2 diabetes mellitus (T2DM) and chronic periodontitis.

This study was designed as a randomized, controlled, full-mouth, 6-month clinical trial. 37 patients (20 women and 17 men) with uncontrolled T2DM and chronic periodontitis who were selected from among those admitting to Dentistry Faculty of Inonu University and Turgut Ozal Medical Center completed this study. The patients were divided into two groups. The individuals in the control group underwent placebo laser treatment in addition to scaling and root planing (SRP). The individuals in the study group underwent DL (1 W power) in addition to SRP. Clinical index measurements were performed before treatment (T0), 3 months after treatment (T1), and 6 months after treatment (T2). Plaque index (PI), gingival index (GI), bleeding on probing (BOP), clinical attachment level (CAL), and probing depth (PD) were measured to determine periodontal status. HbA1c and C-reactive protein (CRP) levels were also analyzed using blood samples.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Diabetes Mellitus Periodontal Disease

Interventions

Laser groupDEVICE

Laser application in addition to SRP

Control groupDEVICE

Placebo laser application in addition to SRP

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Having a diagnosis of type-2 DM according to the ADA criteria for at least two years before the study, HbA1c⩾7%,28 * Having no change in antidiabetic drugs in the last 3 months, * Having no major diabetes complications (because chronic complications of diabetes complicate metabolic control), * Presence of generalized CP,29 * Presence of an area with a pocket depth of 4-7 mm in at least four teeth in the upper jaw, * Presence of at least 20 teeth in the mouth, * Having no any systemic illness except for DM, * Having no smoke, * Receiving no periodontal treatment in the last 12 months, * Receiving no antibiotics or anti-inflammatory drugs for a long period in the last 6 months, * Not being pregnant or not to breastfeed, * Having no third molars. Exclusion Criteria: \-

Locations (1)

Abubekir Eltas

Malatya, Turkey (Türkiye)

Outcomes

Primary Outcomes

Laboratory findings

Serum HbA1c levels were measured using the high-performance liquid chromatography method.

Time frame: Six months

Secondary Outcomes

Clinical findings

Probing depth (PD) was measured the distance between the gingival margin and the deepest aspect of the pocket (mm).

Time frame: Six months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.