Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
100
This drug is in our routine use of neuroanesthesia, are given for facilitate brain relaxation
Fudan University affiliated Huashan Hospital
Shanghai, Shanghai Municipality, China
brain relaxation score
difference in brain relaxation after drug administration The assessment was performed using a 4-point scale, 1 denoting bulging or the condition that additional methods for brain relaxation are immediately and always required in order to continue the surgical procedure because of brain swelling; 2, firm or the condition that additional methods for brain relaxation are occasionally required to continue the surgical procedure; 3, adequate; 4, perfectly relaxed. In all patients, the degree of brain relaxation was assessed at the time of dural opening and satisfactory brain relaxation was defined as a brain relaxation score of 3 or 4. All the Secondary Outcome Measures below are observed the safety for intraoperative brain debulking during elective supratentorial craniotomy
Time frame: just before dural opening
Blood sodium levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Blood potassium levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Blood chlorine levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Blood lactate levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Fluid balance during operation
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
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