The study validates prospectively a new endoscopic scoring system (Gothenburg Intestinal Transplant Endoscopy Score, GITES) designed to summarize and stratify the abnormal ileal endoscopic findings after intestinal transplantation. GITES is a five-tier, four grade score which asseses mucosal friability, mucosal erythema and mucosal injury (ulcerations) as well as villous changes according to severity. These features (i.e., endoscopic descriptors) are also grouped from mild to very severe in the same sequence as observed during the progression of several pathologic conditions encountered after intestinal transplantation (acute rejection, infectious enteritis).
Study Type
OBSERVATIONAL
Enrollment
80
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, United States
RECRUITINGFavaloro Foundation University Hospital
Buenos Aires, Argentina
RECRUITINGHospital Universitario "La Paz"
Madrid, Spain
RECRUITINGSahlgrenska University Hospital
Gothenburg, Sweden
RECRUITINGEndoscopic evaluation
To validate the GITES grading system in intestinal graft recipients using high-definition white light endoscopy
Time frame: 7 years
Correlations with histology and Clinical course
Comparison and correlation of clinical and histopathological data with endoscopic findings to evaluate the conditions leading to the mucosal alterations defined by established endoscopic descriptors and GITES.
Time frame: 1 year
Performance of the grading score
Endpoints include sensitivity, specificity, positive predictive value, negative predictive value as well as inter- and intraobserver variation in the evaluation of the mucosal alterations by means of GITES and using high-definition white light endoscopy;
Time frame: 1 year
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