The purpose of this study is to determine whether BMS-986299 both by itself and in combination with Nivolumab and Ipilimumab is safe and tolerable in the treatment of advanced solid tumors. In addition, the ability of study drugs to stimulate an immune response against cancer will be investigated.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
82
Specified dose on specified day
Specified dose on specified day
Specified dose on specified day
Local Institution - 0003
La Jolla, California, United States
Local Institution
Orange, California, United States
University of California Davis Medical Center
Sacramento, California, United States
Local Institution
Incidence of dose-limiting toxicities (DLTs)
Time frame: Up to 28 days
Incidence of adverse events (AEs)
Time frame: Approximately 2 years
Incidence of clinical laboratory abnormalities
Time frame: Approximately 2 years
Incidence of serious adverse events (SAEs)
Time frame: Approximately 2 years
Incidence of AEs leading to discontinuation and deaths
Time frame: Approximately 2 years
Maximum observed plasma concentration (Cmax)
Time frame: Approximately 2 years
Time of maximum observed plasma concentration (Tmax)
Time frame: Approximately 2 years
Area under the serum concentration-time curve from time zero to time of last quantifiable concentration [AUC(0-T)]
Time frame: Approximately 2 years
Area under the plasma concentration-time curve from time zero to 24 hours postdose [AUC(0-24)]
Time frame: Approximately 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
New Haven, Connecticut, United States
Local Institution
Detroit, Michigan, United States
Washington University
St Louis, Missouri, United States
Local Institution
Portland, Oregon, United States
Local Institution
Pittsburgh, Pennsylvania, United States
MD Anderson Cancer Center
Houston, Texas, United States