CPAP for OSA on Myocardial Salvage After pPCI for STEMI Patients

Inclusion Criteria: 1. 18 to 80 years old 2. First-time STEMI 3. Successful PPCI (≥1 coronary artery) within 24h after symptom onset 4. Moderate to severe OSA (AHI≥15) 5. Written informed consent Exclusion Criteria: 1. Prior myocardial infarction 2. Prior myocardial revascularization (PCI or CABG) 3. Cardiogenic shock (mean arterial pressure \<60mmHg), severe heart failure (Killip≥3) 4. LM or multivessel disease indicated for CABG 5. History of stroke 6. Severe insomnia, chronic sleep deprivation, abnormal circadian rhythm (sleep \<4h/night) 7. Severe COPD: FEV1/FVC \<70% or FEV1 \<50% predicted value (within 4 weeks) 8. Predominantly central sleep apnea (≥25% central events or central AHI ≥10/h) 9. Previous or current use of CPAP 10. Severe comorbidities: eg. malignancy (life expectancy \<2 years) 11. Known or planned pregnancy 12. Known contraindication to CMR 13. Patients with contraindication to CPAP or who cannot tolerate it 14. Participation in other clinical trial in recent 3 months 15. Any condition that in the opinion of investigator that may jeopardize patient compliance, eg. significant memory, perceptual, or behavioral disorder, depression, severe alcohol consumption, or a history of noncompliance