Previous literature has found potential association between selenium deficiency and inactivated glutathione peroxidase and deiodinase, which may contribute to subsequent elevation of T4 and ratio of T4/T3. Conduction of a case-control study (ID: Liuyanping3) has been applied on Clinicaltrials.gov to further elucidate effect of selenium deficiency on thyroid function. Based on its data, the investigators will perform a randomized, placebo-controlled,single-blinded crossover study on 20 participants with selenium deficiency to verify health consequence of selenium.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
20
administration of selenium-rich corn powder 20g/d offering selenium 100μg/d
ordinary corn powder,20g/d(selenium contain \<0.5ug/20g).
comparison of thyroid function
comparison of thyroid function between administration of selenium supplementation and placebo
Time frame: plasma sample will be collected at -1w/4w/8w/12w
comparison of serum selenium
comparison of serum selenium between administration of selenium supplementation and placebo
Time frame: plasma sample will be collected at -1w/4w/8w/12w
comparison of erythrocyte glutathione peroxidase activity
comparison of erythrocyte glutathione peroxidase activity between administration of selenium supplementation and placebo
Time frame: plasma sample will be collected at -1w/4w/8w/12w
comparison of serum deiodinase activity
comparison of serum deiodinase activity between administration of selenium supplementation and placebo
Time frame: plasma sample will be collected at -1w/4w/8w/12w
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