The purpose of the study is to determine the efficacy of IV acetaminophen when administered to neurosurgical patients at the beginning and end of their surgery. If the result is improved pain control with less opioid consumption postoperatively, then those patients may also experience less opioid related side effects such as nausea/vomiting, pruritus, and sedation. While numerous other studies have failed to show a benefit of IV acetaminophen after neurosurgical procedures, we are studying the administration of 1 g in two doses over the course of the operation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
27
Acetaminophen 1 g intravenous given at the beginning and end of surgery.
Placebo to match acetaminophen given at the beginning and end of surgery.
Stanford University Medical Center
Palo Alto, California, United States
Post-operative Opioid Consumption
From nursing records how much opioid was administered to each patient post-operatively. Opioid use was measured in micrograms (ug) of fentanyl.
Time frame: Up to 24 hours post-operative
Post-operative Pain
Patients were asked to rate their pain on a scale of 1 to 10, with 1 being least pain, and 10 being most pain. Pain was assessed continually once per hour during the post-operative period and the average pain score calculated per participant. The average of the participants' average scores is presented for each group.
Time frame: Up to 24 hours post-operative
Count of Participants Requiring Anti-emetic Administration
Time frame: Up to 24 hours post-operative
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