MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients

Mayo Clinic8 enrolled

Overview

Can an MRI detect and monitor the inflammatory and fibrotic possess in patients with Eosinophilic Esophagitis

MRI will be performed on a 1.5T magnet. Patients will be scanned in an oblique prone position similar to how esophageal distention is assessed at barium fluoroscopy. The following sequences and rationale will be used for the examination: A sagittal 50mm thick multiphase FIESTA and multiphase SSFSE will be performed while the patient drinks water. The temporal resolution of the images will be approximately 1 image every 1.5-2 seconds. The images will be used to assess the lumen caliber and the wall thickness during maximal distension as pseudothickening can occur with decreased luminal distension. Sagittal SSFSE with fat suppression, sagittal FRFSE T2-weighted images with fat suppression, axial DWI and sagittal DWI will be performed to asses for edema and inflammation within the esophageal wall. axial FS SSFSE or FIESTA will be performed and targeted to the region of stricturing. Dynamic sagittal imaging will be performed following IV contrast to assess for mural hyperenhancement which can be seen mural inflammation and delayed enhancement which can be seen in fibrosis. Sequential acquisitions will be performed beginning at 40 seconds following IV contrast injection. Delayed acquisitions will be performed at 5 min and 7 min. Patients will be asked to perform swallowing during the image acquisition to reduce the potential for pseudoenhancement secondary to under distension.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Eosinophilic Esophagitis

Interventions

MRI to detect inflammation and fibrosis in subjects with EoEDIAGNOSTIC_TEST

MRI will be performed on a 1.5T magnet. Patients will be scanned in an oblique prone position similar to how esophageal distention is assessed at barium fluoroscopy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion criteria: * Adults ages 18-70 years of age * Diagnosis of EoE, i.e. symptoms of esophageal dysfunction with histologic finding of 15 or more eosinophils per high power field on esophageal biopsy despite 8 weeks of high dose proton pump inhibitor therapy. * All Subjects diagnosed with Eosinophilic Esophagitis pre and pose therapy Exclusion criteria: * Clinical evidence of infectious process potentially contributing to dysphagia (e.g. candidiasis, CMV, herpes) * Other cause of dysphagia identified at endoscopy or esophagram (e.g. reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm) * Esophageal minimal diameter \< 13 mm on structured barium esophagram * Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy * Pregnant women * Presence of body metallic fragments or devices that prohibit use of MRI * History of renal disease * eGRF \<30

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Measurement of distinct inflammatory and fibrotic components of the esophageal stricture in patients with eosinophilic esophagitis

At 5,15 and 25 cm above the gastroesophageal junction and in areas of obvious esophageal thickness, digitized areas of inflammation and fibrosis will be measured individually and as a proportion of overall esophageal diameter in that area before and after steroid treatment.

Time frame: 1 day

Secondary Outcomes

Barium Esophagram

The barium esophagram will measure moderate stricture formation to delineate the groups- Group 1.(narrowed segment \<8 cm in length and lumen diameter \> 12mm) and Group 2- 10 will have small caliber esophagus (a narrowed segment \>8 cm in length with minimum diameter \< 10mm).

Time frame: 1 day

Eosinophilic Esophagitis Activity Index (EEsAI)

Questionnaire developed to measure dysphagia - using the pro scoring method

Time frame: 1 day

Data from ClinicalTrials.gov

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