Matched Pair Study - Kinematic Vs Mechanical Alignment

Inclusion Criteria: 1. Patients presenting with disease that meets the indications for use for Medacta implants defined by this study (on-label use). 2. Patients necessitating primary Total Knee Replacement 3. Patients who are willing and able to provide written informed consent for participation in the study. Written informed consent must be obtained prior to the patient's surgery. Exclusion Criteria: 1. Those with one or more medical conditions identified as a contraindication defined by the labeling on Medacta implants used in this study. 2. Previous osteotomy around the knee 3. Ligament instability likely to require higher level of constraint 4. Previous infection or inflammatory disease 5. Extraarticular deformities for which a femoral intramedullary guide rod can't be inserted into the canal and use of Computer Assisted Orthopaedic Surgery (CAOS) or Patient Specific Instrumentation (PSI) is required.