Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbial disorders such as autoimmune thyroiditis However, there is no report on the relationship between oral microecology and autoimmune thyroiditis. Therefore, our group will study the correlation between oral microbiota and AITD.
Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbiological disorders. Intestinal microelements Both ecology and oral microecology belong to the category of microorganisms. It has been reported in the literature that intestinal microecology occurs disorder of autoimmune thyroiditis. However, there is no report on the correlation between oral microecology and autoimmune thyroiditis. When oral microbe flora When the immune system is disrupted, the immune balance is broken, the immune system is over-active, and the autoimmune disease (AID) is lost to the autoantigens and non-pathogenic commensal microbial flora antigens, including rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, inflammatory bowel disease, and allergic diseases. However, the association between oral microbial flora and AITD remains unclear. . Therefore, the research group will carry out the correlation between oral microbial flora and AITD.
Study Type
OBSERVATIONAL
Enrollment
120
Patients who developed GD received methimazole treatment
Patients who developed GD received propylthiouracil treatment
First affiliated hospital of Harbin medical university
Harbin, Heilongjiang, China
RECRUITINGTranscriptional changes in oral microbiota
The microbiota measured by 16S rRNA gene
Time frame: Baseline, 3 months, 6 months, 9 months, 12 months
Serum thyroid function changed
Serum thyroid function measured by Immunohistochemistry
Time frame: Baseline, 3 months, 6 months, 9 months, 12 months
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