The objective of this study was to evaluate vitamin B deficiency (particularly vitamin B6 deficiency) in diabetic patients in Germany in relation to the presence or absence of proteinuria, and global vascular risk.
This observational study recruited either control subjects or patients with type 2 diabetes for over 5 years and collected information on cardiovascular risk factors. Fasting blood samples and urine were collected and biomarkers of B-vitamins were measured and were related to renal function or to global cardiovascular risk. Global cardiovascular risk was calculated from established models that include Routine clinical and laboratory markers such as plasma lipids, smoking, hypertension, and BMI. we measured the following markers: Glucose (fasting plasma glucose); HbA1C; serum creatinine; Glomerular filtration rate (GFR), urinary Albumin, C-reactive Protein, Soluble vascular cell adhesion molecule 1 (sVCAM-1), cystatin C, vitamin B1, vitamin B12, holotranscobalamin, methylmalonic acid, homocysteine, and different vitamin B6 forms.
Study Type
OBSERVATIONAL
Enrollment
174
Test if patients with diabetes have different blood concentrations of vitamin biomarkers compared with control subjects and if vitamin levels in the patients will differ according to renal damage.
The difference in serum vitamin B12 levels between cases and controls
Compare mean levels of the controls with those in the patients
Time frame: Baseline
The difference in serum vitamin B1 between cases and controls
Compare mean levels of the controls with those in the patients
Time frame: Baseline
The difference in serum vitamin B6 concentrations between cases and controls
Compare mean levels of the controls with those in the patients
Time frame: Baseline
The difference in serum vitamin B12 between patients with and those without albuminuria
Compare mean levels of diabetes patients with microalbuminuria and those without microalbuminuria
Time frame: Baseline
The difference in serum and urine vitamin B1 between patients with and those without albuminuria
Compare mean levels of diabetes patients with microalbuminuria and those without microalbuminuria
Time frame: Baseline
The difference in serum and urine vitamin B6 vitamers between patients with and those without albuminuria
Compare mean levels of diabetes patients with microalbuminuria and those without microalbuminuria
Time frame: Baseline
The difference in serum and urine vitamin B6 vitamers between patients with advanced global vascular risk versus those with a low vascular risk
Compare mean levels of diabetes patients with microalbuminuria and those without microalbuminuria
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Time frame: Baseline