The aim of the study is to compare the efficiency on respiratory failure regression of high-flow nasal oxygen therapy versus standard oxygen in patients admitted to the ED for de novo acute respiratory failure.
Prospective observational before-after study at the ED in two French centers. Selection of patients with acute hypoxemic respiratory failure at the ED. Application of oxygen strategy according to the period: * before period: standard oxygen delivered through nasal cannula, face mask or non-rebreathing reservoir mask, with a flow rate adjusted to maintain a pulse oxymetry of at least 92%. * after period: high-flow oxygen therapy continuously applied via large-bore nasal prongs with a gas flow rate of 50 L/min and a FiO2 adjusted to maintain a pulse oxymetry at least 92%.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
102
HFNC is continuously applied via large-bore nasal prongs with a gas flow rate of 50 L/min and a FiO2 adjusted to maintain a pulse oxymetry at least 92%
nasal cannula, face mask or non-rebreathing reservoir mask
CHG de Niort
Niort, France
CHU Poitiers
Poitiers, France
complete regression of respiratory failure
respiratory rate less than 25 breaths per minute and regression of signs of increased work of breathing
Time frame: one hour after initiation of oxygen strategies
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