Alzheimer disease (AD) is a dementing illness characterized by progressive neuronal degeneration, gliosis, and the accumulation of intracellular inclusions and extracellular deposits of amyloid in discrete regions of the basal forebrain, hippocampus, and the association cortices. Mild cognitive impairment (MCI) refers to individuals with cognitive impairment (often memory loss) that fails to meet clinical criteria for AD or another dementing illness.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
25
cysteine-rich whey protein isolate
Memory Clinic/Jewish General Hospital
Montreal, Quebec, Canada
RECRUITINGChange in GSH levels in the brain
Change in cerebral Glutathione levels of MCI patients measured by MRI/MRS scans
Time frame: Baseline compared to month 6 (180 days)
Change in plasma GSH:GSSG ratios measured by HPLC
To evaluate positive correlation between plasma GSH:GSSG ratios and changes in cerebral GSH
Time frame: Baseline compared to month 6 (180 days)
Evaluation of neuropsychological and cognitive functions
The Memory Clinic of JGH Neuropsychological evaluation questionnaire will be used to measure both neuropsychological and cognitive functions
Time frame: Baseline compared to month 6 (180 days)
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