The primary progressive aphasia (PPA) is a neurodegenerative condition characterized by a gradual, irreversible decline of language function (Mesulam, 2001). There are no known treatments for PPA so far. The relentless progression of PPA symptoms eventually leads to a profound impairment in communication ability and, ultimately, to more generalized deficits of cognition. Some cases and small studies reported that Transcranial Magnetic Stimulation (TMS), one of the non-invasive neuromodulation tech, can be employed to facilitate language production and improve the language ability in patients with PPA. Herein we will explore the tolerance and efficacy of TMS for the treatment of PPA by the randomized controlled trial .Meanwhile the functional MRI tech will be used to investigate the neural network changing in the procedure
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
The device is made in London,UK
Boston naming test evaluation
Assessment of the language production
Time frame: Baseline
Boston naming test evaluation
Assessment of the language production
Time frame: One month(just after 20 times rTMS treatment)
Western Aphasia Battery(WAB) Speech fluency
Assessment of the language production
Time frame: Baseline
Western Aphasia Battery(WAB) Speech fluency
Assessment of the language production
Time frame: One month(just after 20 times rTMS treatment)
Repetition Part of WAB
Assessment of the repetition ability
Time frame: Baseline
Repetition Part of WAB
Assessment of the repetition ability
Time frame: One month(just after 20 times rTMS treatment)
Word recognition Part of WAB
Assessment of the reading
Time frame: Baseline
Word recognition Part of WAB
Assessment of the reading
Time frame: One month(just after 20 times rTMS treatment)
Syntax comprehension Part of Bilingual Aphasia Battery( Standard modern Chinese version)
Assessment of the grammar ability
Time frame: Baseline
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Syntax comprehension Part of Bilingual Aphasia Battery( Standard modern Chinese version)
Assessment of the grammar ability
Time frame: One month(just after 20 times rTMS treatment)
fMRI parameters(strength, efficiency, clustering coefficient, and characteristic path length)
Graph theoretical analysis of the speech/language network
Time frame: Baseline
fMRI parameters(strength, efficiency, clustering coefficient, and characteristic path length)
Graph theoretical analysis of the speech/language network
Time frame: One month(just after 20 times rTMS treatment)