Colorectal cancer is the third most commonly diagnosed cancer in the world. The 5-years survival rate depends on the tumor stage and grade at patient presentation. Individual treatment strategy based on the tumor stage and grade should be applied to improve the prognosis, So the pre-operative diagnostic evaluation and grading of colorectal cancer are important.
Diagnosis of cancer colon is usually based on colonoscopy which provides direct visualization of the lesions and allows for biopsies. However the pre-operative specimens from endoscopic biopsies sometimes fail to grade tumor because of the lack of sufficient tissue. Recent improvements in computed tomography have allowed for minimally invasive evaluation of cancer colon. Quantitative iodine density measurement can be used to differentiate low and high grade colorectal cancer. However, debate continues regarding the correlation between tumor grade and computed tomography perfusion parameters of colorectal cancer demonstrating the need for further investigation in this area of research.
Study Type
OBSERVATIONAL
Enrollment
50
Pre-contrast images will be obtained to identify the colorectal tumor location. Then Fifty milliliters of iopromide (Ultravist ) will be injected intra-venously at rate of 5 milliliter per second via an automatic pump injector for computed tomography perfusion scans. Computed tomography perfusion scans will be performed at the mid-portion of the tumor for 60seconds beginning 5 seconds after contrast injection. Then arterial input will be defined by using the mouse to place a circular region of interest and the tumor region of interest will be placed on the most enhanced area of the tumor. Tumor blood flow, blood volume, mean transient time \& permeability surface measurements will be obtained.
Faculty of Medicine
Asyut, Egypt
Blood flow of tumor
Accuracy of blood flow of the tumor in prediction of tumor grade in correlation with histopathological results
Time frame: One month
Blood volume of the tumor
Accuracy of blood volume of the tumor in prediction of tumor grade in correlation with histopathological results
Time frame: One month
Mean transient time of the tumor
transient time of the tumor in prediction of tumor grade in correlation with histopathological results
Time frame: One month
Permeability surface of the tumor
Accuracy of permeability surface of the tumor in prediction of tumor grade in correlation with histopathological results
Time frame: One month
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