As one of the essential micronutrients, selenium has important biological functions. However, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. Previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( T4) to triiodothyronine (T3). A case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated T4 or T4/T3, which may provide more clues for establishing effective selenium assesment methods.
Study Type
OBSERVATIONAL
Enrollment
200
For this case-control study, no intervention will be administered to participants, only serum sample will be collected for selenium assessment
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
RECRUITINGbetween-group difference in serum selenium
comparison of the mean serum selenium between the two groups
Time frame: up to 24 weeks
between-group difference in serum deiodinase activity
comparison of the mean deiodinase activity between the two groups
Time frame: up to 24 weeks
between-group difference in erythrocyte glutathione peroxidase activity
comparison of the mean erythrocyte glutathione peroxidase activity between the two groups
Time frame: up to 24 weeks
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