Th17 Inducing Cytokines Pregnancy and After Postpartum

Aydin Adnan Menderes University114 enrolled

Overview

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.

IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.

Study Type

OBSERVATIONAL

Enrollment

114

Conditions

Pregnancy

Interventions

Saliva collectionOTHER

GCF collectionOTHER

Eligibility

Sex: FEMALEMin age: 19 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * women 2 and 3 trimester of their pregnancy Exclusion Criteria: * any known systemic disease, * periodontal treatment within the last six months, * patients having less than 10 teeth, * smokers, * individuals with a BMI \> 30 kg/m2, * gestational diabetes and preeclampsia during pregnancy.

Outcomes

Primary Outcomes

Changing Il-17A levels

Salivary and GCF level measured by ELISA

Time frame: 6 month

Secondary Outcomes

Changing IL-6 levels

Salivary and GCF level measured by ELISA

Time frame: 6 month

Changing IL-23 levels

Salivary and GCF level measured by ELISA

Time frame: 6 month

Changing IL-17E levels

Salivary and GCF level measured by ELISA

Time frame: 6 month

Data from ClinicalTrials.gov

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