Safety and Efficacy of Actamax™Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy

Preoperative Inclusion Criteria: * Understand and be able to follow the requirements of the protocol including personally signing and dating an IRB approved Informed Consent Form prior to undergoing any protocol related procedures, * Be a premenopausal female, \> 18 and \< 44 years old, * Be thought to have uterine fibroids requiring laparoscopic abdominopelvic surgery that will require a \> 3 cm posterior uterine incision (including repeat myomectomy/previous uterine artery embolization for fibroid), and/or +/- adhesions, and/or +/- endometriosis, and/or +/- adenomyosis and/or ovarian cyst(s), * Wish to retain her fertility and be considered to clinically benefit from a SLL, in the investigator's opinion, * Have a willingness to undergo a second look laparoscopy if surgeon considers it clinically beneficial to the subject, * Have a negative pregnancy test within 5 days of surgery, * Agree to avoid pregnancy using adequate forms of contraception (oral contraceptive pill, condom, no sexual intercourse), and is aware and agrees to avoid pregnancy for a minimum of 12 weeks or to SLL (whichever is greater) to allow for healing of the uterine scar following myomectomy, * Is willing, able and likely to fully comply with study procedures and restrictions including follow-up, * Be in good health including an ASA (American Society of Anesthesiologists) score of 2 or less, * Have undergone a satisfactory physical and medical assessment with no clinically significant and relevant abnormalities. Intraoperative Inclusion Criteria: * The subject underwent a laparoscopic myomectomy with at least (1) posterior uterine serosal incision of \> 3 cm in length, * The subject meets all intraoperative inclusion/exclusion criteria prior to randomization, And • At the completion of the procedure, before randomization, the surgeon believes that the subject will clinically benefit from a second look laparoscopy to preserve fertility. Preoperative Exclusion Criteria: * Are unable to give their own written informed consent, * Have completed her family planning with no desire to maintain fertility, * Are considered to have no potential clinical benefit from a second look laparoscopy, * Are currently pregnant (including ectopic pregnancy), * Are breastfeeding, * Are within 6 weeks post-partum, * Have received or are expected to receive another anti-adhesive treatment within 30 days prior to enrollment or during enrollment up to adhesion evaluation at second look laparoscopy, * Are currently or have been enrolled within the last 30 days in another interventional study. * Have received or are expected to receive any other investigational product or technique within 30 days prior to or during enrollment, * Have had cancer within 5 years of the initial surgery with the exception of basal cell carcinoma, * Have known allergy to dextran, PEG, or FD\&C Blue #1, * Have had bilateral salpingectomy, * Have had a hysterectomy, * Are scheduled to undergo concomitant non-gynecologic surgery, * Have pre-operative imaging results with: * Largest fibroid diameter \< 2 cm, or * Largest intramural fibroid diameter \>10 cm, or * More than 5 intramural fibroids with a diameter of \> 8 cm, and/or * Adenomyoma \>10 cm. * Have a history where it is expected that complete adhesiolysis will be impossible, * Have clinically significant abnormal blood results, * Have clinically relevant hemochromatosis, hepatic, renal, autoimmune, lymphatic, hematological or coagulation disorders, * Have insulin dependent diabetes mellitus, * Are receiving concurrent systemic corticosteroids, antineoplastic agents and/or radiation therapy, * Have had previous abdominal or pelvic radiation therapy, * Have active pelvic or abdominal infection, or other active infection with fever \>100°F/38°C, * Have a known history of methicillin-resistant Staphylococcus aureus (MRSA), HIV, HBV or HCV. Intraoperative Exclusion Criteria: * Have cancer detected at surgery, * Are pregnant, including ectopic pregnancy, * Have a non-gynecologic surgical procedure or entry into the bowel, bladder, or ureter, * Have a hysterectomy or other gynecologic procedure that would render the subject unable to conceive, * Have incomplete lysis of any pre-existing pathological adhesions, * Have extensive enterolysis, * Have incomplete surgical treatment of endometriosis, * Receive the administration of a product that will interfere with the application of Actamax™ Adhesion Barrier, * Receive the use of an approved or unapproved product or strategy for the purpose of preventing adhesion development, * Receive fibrin glue, surgical sealant, or other hemostatic agent, * Undergo an open procedure (other than mini laparotomy to remove fibroids), * Undergo a posterior colpotomy, * Undergo insufflation with a gas other than CO2, * Undergo Laprolift or similar device for elevation of the abdominal wall, as an alternative to CO2 insufflation, * Undergo abdominal cavity heating, humidification or oxygenation, * Receive irrigants containing, glucocorticoids, antihistamines, heparin or antiseptic additives, * Have any instillates left at the end of surgery, * Have a postoperative drain, * Undergo laparoscopic myomectomy without at least one posterior uterine serosal incision of \> 3 cm in length, * Undergo a diagnostic hysteroscopy or polypectomy or therapeutic hysteroscopy which includes any of the following: 1. Undertaken during or following the laparoscopic myomectomy, 2. Treatment of fibroids \>3 cm, 3. Solution other than Lactated Ringer's Solution (LRS) used for uterine distention, 4. Laparoscopic filming commenced after removal of LRS. * If, in the opinion of the surgeon, subject would have no clinical benefit for a SLL.