M7824 (MSB0011359C) in Combination With Gemcitabine in Adults With Previously Treated Advanced Adenocarcinoma of the Pancreas

* INCLUSION CRITERIA: * Patient must be able to understand and willing to sign a written informed consent document * Age greater than of equal to 18 years. Because no dosing or adverse event data are currently available on the use of M7824 (MSB0011359C) in combination with gemcitabine in patients \<18 years of age, children are excluded from this study, but will be eligible for future pediatric trials * Histologically or cytologically proven pancreatic adenocarcinoma (subjects with endocrine or acinar pancreatic carcinoma are not eligible). * Patients must have disease that is not amenable to potentially curative resection. * Subjects must have progressed on or after standard first-line systemic chemotherapy. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 * Must have evaluable or measurable disease per Response Evaluation in Solid Tumors (RECIST) 1.1. * Adequate hematological function defined by: * white blood cell (WBC) count greater than or equal to 3x10(9)/L * with absolute neutrophil count (ANC) greater than or equal to 1.5x10(9)/L * lymphocyte count greater than or equal to 0.5x10(9)/L, * platelet count greater than or equal to 120x10(9)/L, and * Hemoglobin (Hgb) greater than or equal to 9 g/dL (in absence of blood transfusion) * Adequate hepatic function defined by: * a total bilirubin level less than or equal to 1.5xUpper limit of normal (ULN), * an aspartate aminotransferase (AST) level less than or equal to 2.5xULN, * alanine aminotransferase (ALT) level less than or equal to 2.5Xuln. * Adequate renal function defined by: * Creatinine up to 1.5 upper institutional limits OR creatinine clearance (CrCl) \>50 mL/min/1.73 m\^2 OR within normal as predicted by the Cockcroft-Gault formula: Creatinine Clearance (CrCl)=(140-age) x (weight in kg) x (0.85, if female)/72 x Serum Creatinine (mg/dL) \- The effects of the study treatment on the developing human fetus are unknown; thus, women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) within 28 days prior to study entry, for the duration of study participation and up to 120 days after the last dose of the drug. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. EXCLUSION CRITERIA: * Patients who are receiving any other investigational agents * Prior therapy with any antibody / drug targeting T cell coregulatory proteins (immune checkpoints) such as anti-Programmed cell death protein 1 (PD-1), anti-Programmed death-ligand 1 (PD-L1), or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibody. * Anticancer treatment within designated period before enrollment including: * minor surgical procedure (such as biliary stenting) within 14 days * major surgical procedure or radiation treatment within 28 days * chemotherapy or experimental drug treatment with published half-life known to be 72 hours within 14 days * experimental drug treatment with unpublished or half-life greater than 72 hours within 28 days * radiotherapy for measurable lesions delivered in a normal organ-sparing technique within 21 days (except for palliative radiotherapy) * Concurrent treatment with non-permitted drugs including herbal remedies with immunostimulating properties (for example, mistletoe extract) or known to potentially interfere with major organ function (for example, hypericin). * Previous malignant disease (other than the target malignancy to be investigated in this trial) within the last 3 years. Subjects with a history of cervical carcinoma in situ, superficial or no-invasive bladder cancer, or basal cell or squamous cell carcinoma in situ previously treated with curative intent are NOT excluded. * Rapidly progressive disease which, in the opinion of the Investigator, may predispose to inability to tolerate treatment or trial procedures. * Subjects with active central nervous system (CNS) metastases causing clinical symptoms or metastases that require therapeutic intervention are excluded. Subjects with a history of treated CNS metastases (by surgery or radiation therapy) are not eligible unless they have fully recovered from treatment, demonstrated no progression for at least 2 months, and do not require continued steroid therapy. Subjects with CNS metastases incidentally detected during Screening which do not cause clinical symptoms and for which standard of care suggests no therapeutic intervention is needed are eligible. * Receipt of any organ transplantation, including allogeneic stem-cell transplantation, except of transplants that do not require immunosuppression (e.g., corneal transplant, hair transplant) * Significant acute or chronic infections including tuberculosis (history of exposure or history of positive tuberculosis test; plus, presence of clinical symptoms, physical or radiographic findings) * Active autoimmune disease that might deteriorate when receiving an immunostimulatory agent with the exceptions: * diabetes type I, vitiligo, alopecia, psoriasis, hypo- or hyperthyroid disease not requiring immunosuppressive treatment are eligible; * subjects requiring hormone replacement with corticosteroids are eligible if the steroids are administered only for the purpose of hormonal replacement and at doses less than or equal to 10 mg of prednisone or equivalent per day; * administration of steroids for other conditions through a route known to result in a minimal systemic exposure (topical, intranasal, intro-ocular, or inhalation) is acceptable. * Known severe hypersensitivity reactions to monoclonal antibodies (Grade greater than or equal to 3 National Cancer Institute Common Terminology Criteria in Adverse Events (NCI-CTCAE) v4.03, any history of anaphylaxis or history of uncontrolled asthma. * Known severe hypersensitivity to gemcitabine. * Female patients who are pregnant or breastfeeding. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with M7824 in combination with gemcitabine, breastfeeding should be discontinued. * Known alcohol or drug abuse. * Clinically significant cardiovascular / cerebrovascular disease as follows: cerebral vascular accident / stroke (\< 6 months prior to enrollment), myocardial infarction (\< 6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class greater than or equal to II), or serious cardiac arrhythmia. * Clinically relevant diseases (for example, inflammatory bowel disease) and/or uncontrolled medical conditions, which, in the opinion of the Investigator, might impair the subject's tolerance or ability to participate in the trial. * Vaccine administration of live vaccines within 28 days of enrollment. * Patients with known contrast allergies requiring pre-medication with steroids. * Human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV) positive patients on antiviral drugs are excluded due to the absence of previous experience with concurrent use of antiviral medications and the investigational drug product to be evaluated in the current study and possible for adverse pharmacokinetic and/or pharmacodynamic interactions. * Known inherited bleeding disorder and/or history of bleeding diathesis such as von Willebrand factor (vWF) deficiency.