TGFB1 And LAMA1 Gene Polymorphisms in High Myopia

Ege University151 enrolled

Overview

The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications. Seventy-four children with high myopia (≥6 diopters \[D\]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

DOUBLE

Enrollment

151

Conditions

High Myopia Gene Mutations

Interventions

TGFB1 AND LAMA1 GENE POLYMORPHISMSGENETIC

we evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia in an attempt to further elucidate the genetic basis of high myopia.

Eligibility

Sex: ALLMin age: 3 YearsMax age: 13 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients under the age of 13 * Patients with cycloplegic refraction values ≥6 D (for study group) * Emmetropic patients (for control group) Exclusion Criteria: * Patients who had additional ocular pathology that may affect refraction (such as glaucoma, cataracts, corneal disease) * Patients with history of ocular surgery

Outcomes

Primary Outcomes

Genetic basis of high myopia

evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia

Time frame: 4 years

Data from ClinicalTrials.gov

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