Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA

University of Rijeka88 enrolled

Overview

This study compares the neuroinflammatory response in patients with hypertensive ICH associated with IVH treated with intraventriculary applied rtPA, and the control group. The inflammatory mediator concentration is analyzed in local cerebrospinal liquor.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypertensive Intracerebral Hemorrhage Intraventricular Hemorrhage Brain Injuries

Interventions

intraventricual recombinant tissue plasminogen activator applicationDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects with primary ICH with IVH * ICH score 2-4, , with origin of the hematoma in the basal ganglia and blood in the third and/or ventricle * Patient is not considered a surgical candidate by neurosurgery service Exclusion Criteria: * No history of diseases or drugs that affect the immunological system. * ICH score 1 and 5 * Current participation in another research drug treatment protocol * Previously known intracranial arteriovenous malformation or aneurysms * Intracerebral hematoma considered to be related to trauma * ICH is located in the pons * Blood in the subarachnoid space visualized on CT scan

Outcomes

Primary Outcomes

Cytokine concentration difference between two groups

Cytokine concentration measured from CSL

Time frame: Samples taken on day 0, day 1, day 3 and day 7.

Data from ClinicalTrials.gov

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