Cognitive Impairement In Frontotemporal Dementia

University of Pennsylvania997 enrolled

Overview

This is an observational study that aims to better understand the genetic causes of frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead to better diagnostics and future treatments.

Comparative and longitudinal studies reveal clinical differences between subgroups of patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA), Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC), and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy and fMRI studies show correlated neural defects in FTD subgroups. The investigators will obtain converging evidence from multiple sources to test hypotheses about the neural basis for cognitive functions such as semantic memory, grammatical processing, and social functioning in these FTD subgroups, while improving clinical care for these patients. Recent studies have linked progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. The investigators will obtain comparable neuropsychological and biomarker data in order to compare these patient groups.

Study Type

OBSERVATIONAL

Enrollment

997

Conditions

Frontotemporal Degeneration Progressive Supranuclear Palsy Multiple System Atrophy

Interventions

None-Observation OnlyOTHER

No intervention-this is an observational study

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Individuals who have been diagnosed with FTD, PSP, and MSA Exclusion Criteria: * Individuals under 18 years of age * People with pacemakers or certain metallic implants * pregnant women

Locations (1)

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Progression

Changes over time in MRI and cognitive testing data.

Time frame: This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed

Secondary Outcomes

Impaired semantic memory in Semantic Dementia (SD).

The impact of cortical atrophy on language processing.

Time frame: This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed

Data from ClinicalTrials.gov

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