Effect of THRIVE During Apneic Oxygenation in General Anesthesia on Biomarkers

Karolinska University Hospital30 enrolled

Overview

Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as biological stress response detected by blood-bourne biomarkers before implementing it into clinical practice.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Anesthesia Oxygen Toxicity

Interventions

Apnoeic oxygenation using THRIVEDEVICE

Apnoeic oxygenation using THRIVE

Endotracheal intubation and mechanical ventilationDEVICE

Endotracheal intubation and mechanical ventilation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Adults, \>18 years old. 2. Laryngeal-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery). 3. Capable of understanding the study information and sign the written consent. Exclusion Criteria: 1. American Society of Anaesthesiologist severity score \>2 2. New York Heart Association score \>2 3. Pacemaker or ICD. 4. Body Mass Index \>35 5. Pregnancy 6. Manifest cardiac failure or coronary disease 7. Severe gastrointestinal reflux. 8. Neuromuscular disorder

Locations (1)

Karolinska University Hospital

Stockholm, Sweden

Outcomes

Primary Outcomes

Oxidative stress

Biomarkers of oxidative stress such as Thiobarbituric acid reactive substances, Advanced Oxidation Protein Products,Reactive oxygen species and total antioxidant capacity in blood samples