Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients

National University of Singapore51 enrolled

Overview

Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant. At baseline, 3rd month and 6th month, clinical parameters and cytokine pattern in gingival crevicular fluids (GCFs) were analysed.

Periodontal parameters and cytokine IL-1β, IL-6, IL-8, TNF-α, MMP-8 levels were analysed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Periodontitis, Adult Periodontal Pocket Periodontitis Periodontal Attachment Loss

Interventions

SRP and Fotosan 630DEVICE

After isolating the test quadrants with cotton roll, toluidine blue was applied into the deep pockets (PD ≥ 4mm) at the test quadrants for 10 seconds, followed by inserting a perio tip (15 or 21 mm depending on the depth of the pocket) that connected to a LED emitting device, and light was emitted for 20 seconds. Toluidine blue in the deep pocket was removed by injecting normal saline into the pocket.

Eligibility

Sex: ALLMin age: 21 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults who were medically fit or have medical condition that did not alter the outcome of periodontal treatment. * Females who were not pregnant or nursing. * Controlled diabetes mellitus with HbA1c \< 7.5 mmol/L. * Not on any antibiotics or steroids 3 months prior to periodontal treatment. * Diagnosed to have either localized or generalized chronic or aggressive periodontitis (Armitage, 1999) with all 4 quadrants having at least 2 sites with probing depth ≥ 4 mm. * Consented to follow the non-surgical periodontal treatment (scaling and root planing) with PDT throughout the period of study, i.e. approximately 6 months. Exclusion Criteria: * Allergic to photosensitizer or dye * Pregnant lady and nursing mothers * Uncontrolled diabetes