The Patients' Experience After Stem Cell Transplant

University of Nebraska110 enrolled

Overview

This study will examine how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; whether these changes affect day-to-day activities and quality of life and how thinking and memory abilities are affected by genetics, depression, anxiety and physical function. Genetics and other factors may affect the brain's chemicals or structure, and may increase risk for negative effects on thinking and memory.

In this study, the investigators are looking to understand: 1) how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; 2) whether these changes affect day-to-day activities and quality of life; and 3) how thinking and memory abilities are affected by genetics, depression, anxiety and physical function. Genetics and other factors may affect the brain's chemicals or structure, and may increase risk for negative effects on thinking and memory. Participants will undergo neurocognitive testing along with the collection of a saliva sample and completing a battery of questionnaires and assessments.

Study Type

OBSERVATIONAL

Enrollment

110

Conditions

Stem Cell Transplant Complications

Eligibility

Sex: ALLMin age: 60 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Between the ages of 60-85 * Diagnosed with a hematological malignancy * Is considering an autologous or allogeneic stem cell transplant OR has undergone stem cell transplant in the past 12 months and seen by the PI for pre-transplant evaluation. * Is able to read, write, speak, and understand English Exclusion Criteria: * As per self report or medical record, history of central nervous system involvement and/or history of cranial irradiation or intrathecal chemotherapy except for patients with history of prophylactic intrathecal chemotherapy. * As per self report or medical record, history of stroke, head injury, neurosurgery, seizure disorder, or demyelinating disorder. * As per self report or medical record, history of substance use disorder. * As per self report or in the judgement of the consenting professional, uncorrected vision loss. * As per self report or medical record, primary psychiatric disorder necessitating inpatient treatment in the last 12 months. * As per self report or medical record, history of allogeneic and or autologous stem cell transplant.

Locations (1)

University of Nebraska Medical Center

Omaha, Nebraska, United States

Outcomes

Primary Outcomes

Assess differences with cognitive function in older patients undergoing allogeneic or autologous stem cell transplant at 4 timepoints.

Cognition will be measured using a neuropsychological battery.

Time frame: Before transplant; Post Transplant at 100 days, 6 months, and 12 months

Secondary Outcomes

Assess quality of life of of older patients undergoing allogeneic and autologous transplant at 4 timepoints.

Quality of life will be measured with the EORTC Quality of Life-30C questionnaire.

Time frame: Before transplant; Post Transplant at 100 days, 6 months, and 12 months

Assess activity engagement of older patients undergoing allogeneic and autologous transplant at 4 timepoints.

Activity engagement will be measured with the Activity Card Sort-modified.

Time frame: Before transplant; Post Transplant at 100 days, 6 months, and 12 months

Describe genetic variations in genes potentially involved in cognitive function and cancer treatment.

A saliva sample will be collected to look at genetic variations.

Time frame: 1 time collection: Before transplant

Data from ClinicalTrials.gov

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