Study of MeRes100 in the Treatment of Patient With Coronary Artery Disease.

Inclusion Criteria: * General inclusion criteria: 1. Age ≥ 18 and ≤75years old, man or non-pregnant or non-lactating woman. 2. Subjects with asymptomatic ischemic evidence, stable or unstable angina, or old myocardial infarction \>7 days, suitable for selective PCI. Subjects without contraindications of coronary artery bypass grafting. 3. Subjects be able to understand the purpose of this study, volunteer to participate and sign informed consent, willing to accept invasive imaging follow-up. Angiographic inclusion criteria: 1. One de novo target lesion or up-to two de novo target lesions in different epicardial vessels: Different epicardial vessels are defined as left anterior descending artery (LAD) and its branches, left circumflex artery (LCX) arteries and its branches, and right coronary arteries (RCA) and its branches. Thus, for example, the subject must not have two target lesions required to be treated at the LAD and its branches at the same time. 2. Target lesion diameter stenosis ≥ 70% (or ≥ 50% simultaneously shall have clinical evidence of myocardial ischemia), and TIMI flow grade ≥1. 3. Target lesion length ≤ 24mm (estimated visually); reference vessel diameter between ≥ 2.75 mm to ≤ 4.00 mm. 4. Each target lesion can be fully covered by one scaffold. Exclusion Criteria: * General exclusion criteria: 1. Any non-target lesion in coronary artery needs to be treated simultaneously or selectively (anticipation within 1 year), non-target lesion defined as any lesion that does not fulfill the inclusion/exclusion criteria. 2. Any newly onset acute myocardial infarction within 1 week (\< 7days) or, myocardial enzyme has not return to normal level (clinically non-significant) after myocardial infarction. 3. Subject has undergone prior PCI within the target vessel during the last 12months or plans to receive another PCI within 6months or subject with history of CABG. 4. Subjects with severe heart failure, such as ≥ grade III NYHA or left ventricular ejection fraction \<30% (accessed by ECHO/ultrasound or left ventricular angiography). 5. Blood tests shows the platelet count is less than 100 × 109 / L, or more than 700 ×109 / L, the white blood cells count is less than 3 × 109 / L. 6. Pre-procedure severe liver or kidney functional damaged: serum creatinine\> 1.5mg / dl (132.6μmol / L) or subject is receiving hemodialysis, ALT or AST were three times greater than the upper limit of normal. 7. Subjects with bleeding tendency, active gastrointestinal ulcers, history of cerebral hemorrhage or history of subarachnoid hemorrhage, history within six months of ischemic stroke, contraindications of anti-platelet agents and anticoagulants treatment, and subjects cannot receive anti-thrombolytic therapy. 8. Hypersensitive or allergic to antiplatelet drugs(such as aspirin and clopidogrel), anticoagulant drugs(such as heparin), contrast media, and scaffold components(such as PLLA，PDLLA, sirolimus, everolimus, iridium and platinum). 9. The subject's life expectancy is less than 12 months. 10. Subjects who anticipated in other drug or medical device clinical trial but haven't finished the primary endpoint evaluation visit. 11. The investigators judged that subjects were poorly compliance and unable to complete the study as required. 12. Subjects have accepted substantial organ transplant or ready to undergo organ transplant. 13. Subjects have unstable arrhythmia, such as high-risk ventricular premature beats, and ventricular tachycardia. 14. Subjects are receiving or planning to receive chemotherapy. 15. Subjects have received or planning to receive radiotherapy. 16. Subjects with immunosuppressive or autoimmune diseases, are receiving or planning to receive immunosuppressive therapy. 17. Patients suffering from HIV, HBV or HCV infections 18. Subjects are planning to receive or are receiving long-term anticoagulation therapy, such as heparin, warfarin and similar agents. 19. Subjects are planning to accept selective surgery within 12 months, need to discontinue aspirin or clopidogrel (DAPT therapy). 20. Subjects with diffuse peripheral vascular disease, cannot use 6F catheter. Angiographic exclusion criteria: 1. Subjects with coronary artery triple vessel lesion in LAD, LCX or RCA, all need to be treated. 2. Target lesion locates in left main. 3. Target lesion locates in the aorto-ostial of RCA (within 3 mm of the origin of the RCA). 4. Target lesion locates within 3 mm of the origin of the LM, LAD and LCX. 5. Target lesion involving a bifurcation with a: 1. Side branch ≥2.0 mm in diameter, or 2. Side branch with diameter stenosis ≥ 50%, or 3. Side branch requiring protection guide wire, or 4. Side branch requiring pre-dilatation. 6. Anatomy proximal to or within the lesion that may impair delivery of the MeRes100TM or Xience EES, including: 1. Extreme angulation (≥ 90°) proximal to or within the target lesion 2. Excessive tortuosity (≥ two 45° angles) proximal to or within the target lesion 3. Moderate or heavy calcification proximal to or within the target lesion 7. Target lesion involves a myocardial bridge. 8. Target vessel contains thrombus as indicated in the angiographic images or IVUS. 9. Target vessel has been previously treated with a stent at any time prior to the index procedure such that the MeRes100TM or XIENCE stent would need to cross the stent to reach the target lesion.. 10. Target vessel has been previously treated with a stent and the target lesion is within 5 mm proximal to a previously treated lesion. 11. Chronic complete occlusive lesion (preoperative TIMI grade 0 flow). 12. Target lesion which prevents complete balloon pre-dilatation, defined as full balloon expansion with the following outcomes: 1. Residual %DS is \< 40% (per visual estimation), ( ≤ 20% is strongly recommended). 2. TIMI Grade-3 flow (per visual estimation). 3. No angiographic complications (e.g., no-reflow, distal embolization, side branch closure). 4. No dissections NHLBI grade D-F. 5. No chest pain lasting \> 5 minutes. 6. No ST depression or elevation lasting \> 5 minutes.