The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre. The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after returning to semirecumbent position. Simultaneously blood pressure (BP), pulse rate (PR), pulse oximetric saturation (SpO2) and ECG are recorded. The procedure is performed in ten normal subjects, ten patients recruited in the cardiology outpatient department and ten critically ill patients under analgosedation in the ICU. Analysis includes changes in measured variables and heart rate variability in the frequency domain during the three phases of the experiment.
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Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
11
See above
Regionshospitalet Silkeborg
Silkeborg, Central Jutland, Denmark
Changes in cardiovascular variables I
stroke volume, SV (mL)
Time frame: 10 minutes
Changes in cardiovascular variables II
pulse rate, PR (min\^-1)
Time frame: 10 minutes
Changes in cardiovascular variables III
blood pressure, BP (mmHg)
Time frame: 10 minutes
Changes in cardiovascular variables IV
pulse oximetric saturation, SpO2 (%)
Time frame: 10 minutes
Changes in HRV frequency domain variables V
Heart rate variability, HRV, variables in frequency domain (low frequency, LF, 0.04-0.15 Hz, high frequency, HF, 0.15-0.4 Hz)
Time frame: 10 minutes
Changes in HRV frequency domain variables VI
HRV absolute power (ms\^2, natural logarithm transformed values of absolute powers of very low frequency, VLF, LF, and HF bands)
Time frame: 10 minutes
Changes in HRV frequency domain variables VII
HRV relative power (absolute power/total power)
Time frame: 10 minutes
Changes in HRV frequency domain variables VIII
HRV normalized power (%, normalized units, n.u.)
Time frame: 10 minutes
Changes in HRV frequency domain variables IX
HRV total power given by VLF + HF + LF (ms2) and LF/HF ratio.
Time frame: 10 minutes
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