Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery

Inclusion Criteria: * Subject capable of giving consent * Age 18-80 * Scheduled for open colorectal resection at Cleveland Clinic main campus (with preoperative appointment scheduled at least five days before date of surgery) Exclusion Criteria: * Patient does not speak English * Patient with substance-use disorder (including alcohol) * Patient diagnosed with major depression * Patient currently taking opioids * Previous long-term opioid use (\> 3 months) * Previous opioid use with a dose of \>100 milligram morphine equivalent (MME) * Patient has pain-related disorder (e.g. fibromyalgia, sympathetic dystrophy, etc.) * Documented allergy to pain medication