Study of Ammoxetine Hydrochloride Enteric-coated Tablets in Healthy Subjects

Inclusion Criteria: * Males and females age 18-45 years * Body weight ≥ 45kg (female) or 50Kg (male), 18 ≤ BMI ≤ 26 * Vital signs, physical examinations and laboratory tests and other tests prove participants are healthy * Sign the informed consent form voluntarily and cooperate voluntarily to complete the test Exclusion Criteria: * Allergens (allergic to 2 or more drugs, food or pollen) * comorbid illness (mental illness, liver and kidney disease, gastrointestinal diseases, nervous system disease, or other systemic diseases) * have Clinically significant abnormal screening laboratory values. * Systolic pressure \> 140mmHg or diastolic \> 90 mmHg * Postural hypotension (systolic blood pressure drop by 20mmHg or diastolic blood pressure drop by 10mmHg after standing position) * The QTc period ≥ 450ms (male) or 470ms (female) or has a history of QTc extension * Smoking or alcohol consumption (14 units per week in the previous 4 weeks : 1 unit = beer 285mL, or 25mL of spirits, or 150 mL of wine; Daily smoking ≥ 5) or abusing in past year of drug and other substance * Have donated blood \> 400 ml within 8 weeks prior to screening * Participated in other clinical trials within 3 months prior to screening * Intaked too much caffeinated beverage or food within 4 weeks prior to screening. such as: Coffee, tea, chocolate, cola, red bull (no more than 6 units per day). 1 unit of caffeine = 1 cup of coffee (177.4 mL) = 2 pots of cola (354.9 mL) = 1 cup of tea (354.9 mL) = 1/2 cup energy drink = 85g chocolate * Have taken drugs that changed liver enzyme activity, such as dexamethasone, ketoconazole, rifampicin and omeprazole, were used within 4 weeks prior to screening * Have taken prescription drugs and OTC (except for the occasional use of acetaminophen and nasal sprays), herbs vitamins or minerals within 4 weeks prior to screening. The interval from prior treatment to screening should be at least 5 half-lives metablism which subjected to the longer half-life * Using any psychotropic drug or psychoactive substance * Women were screened for positive blood pregnancy * The subjects and their partners were not willing to take contraceptives during trial and six months after the study * Have a donor plan recently * Have participated in this trial * The researchers believe that anyone who is unfit to participate in this test will be involved