Pregabalin Stabilize Cardiovascular Response to Intubation

Shanghai Zhongshan Hospital90 enrolled

Overview

The purpose of the study is to evaluate whether Pregabalin is safe and effective in stabilizing cardiovascular response to laryngoscopy and tracheal intubation of patients under general anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Effect of Laryngoscopy and Tracheal Intubation

Interventions

PregabalinDRUG

the patients receive 150mg or 300mg pregabalin 60 minutes prior to the surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists(ASA) grade I and II scheduled for elective surgery Exclusion Criteria: * patient refusal. * patients with serious chronic kidney, liver, lungs, or cardiovascular diseases. * allergy to any of the study medications. * patients taking sedation or antihypertensive medications. * suspected difficult intubation or intubation time more than 22s. * pregnant or breastfeeding women. * BMI\>30.

Outcomes

Primary Outcomes

heart rate

effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the heart rate due to laryngoscopy and tracheal intubation

Time frame: heart rate 3 minutes after intubation

Secondary Outcomes

Mean arterial blood pressure

effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the Mean arterial blood pressure due to laryngoscopy and tracheal intubation

Time frame: baseline mean arterial blood pressure before drug administration, heart rate before intubation, heart rate after 0 minute, 1minute, 3minutes, 5 minutes, 7minutes, 10minutes after intubation and before skin incision

systolic blood pressure

effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the systolic blood pressure due to laryngoscopy and tracheal intubation

Time frame: baseline systolic blood pressure before drug administration, heart rate before intubation, heart rate after 0 minute, 1minute, 3minutes, 5 minutes, 7minutes, 10minutes after intubation and before skin incision

diastolic blood pressure

effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the diastolic blood pressure due to laryngoscopy and tracheal intubation

Time frame: baseline diastolic blood pressure before drug administration, heart rate before intubation, heart rate after 0 minute, 1minute, 3minutes, 5 minutes, 7minutes, 10minutes after intubation and before skin incision

Ramsay score

Ramsay score of 300mg pregabalin, 150mg pregabalin premedication versus

Time frame: baseline Ramsay score before drug administration and Ramsay score before intubation

Incidence of all clinical adverse events

Data from ClinicalTrials.gov

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